Over 60 trophies were stolen from the Red Bull Formula 1 team's factory on Friday night, Thames Valley police has confirmed.
Police said on Saturday it had received a call to the Milton Keynes factory at 1:30am reporting a group of around six men used a vehicle to drive through the front entrance to gain access to the factory.
Two cars were used, and police said both are believed to have foreign number plates.
"We are obviously devastated by this serious factory break-in, which saw offenders drive a vehicle through our front entrance and steal more than 60 trophies which took years and hard work to accumulate," said team boss Christian Horner.
"The break-in caused significant damage and was very upsetting for our night officers who were on duty at the time.
"The offenders took items that not only did not belong to them, but which represented the efforts of a group of dedicated, hard-working individuals.
"Beyond the aggressive nature of this break-in, we are perplexed why anyone would take these trophies.
"The value to the team is of course extraordinarily high due to the sheer hard work and effort that went into winning each and every one.
"But their intrinsic value is low; they would be of little benefit to those outside of the team and, in addition to that, many of the trophies on display were replicas.
"The actions of these men mean it's likely that we will have to make our site less accessible in the future, which will be unfair on the hundreds of fans that travel to visit our factory each year to see our trophies and our Formula 1 car.
"We would like to appeal to anyone who knows any information on the whereabouts of these trophies or the offenders involved to contact Thames Valley Police."
Police reported none of the night staff working at the factory were harmed.