Finn Raikkonen completed a morning double when he set the fastest time with a lap of 1:33.212 to lead home teammate Juan Pablo Montoya as McLaren followed up Pedro de la Rosa's double session topping performance from Friday practice.
But the Renault pair continue to sit on McLaren's tails and Fernando Alonso claimed the third best time for the Anglo-French outfit, 0.581 seconds slower than Raikkonen, with his teammate Giancarlo Fisichella fourth.
The session, run under bright but hazy sunshine in temperatures of 22 degrees Celsius, hinted at a strong battle for the constructors' Championship when the two teams go head-to-head on Sunday.
David Coulthard finished a satisfying fifth for Red Bull Racing, just ahead of the sixth-plaed Ferrari of Rubens Barrichello, who won this race last year, and Briton Jenson Button in the leading BAR-Honda machine in seventh.
Outgoing World Champion Michael Schumacher finished eighth fastest, 1.595 seconds off the pace of Raikkonen, with the Williams duo of Antonio Pizzonia and Mark Webber completing the top ten.
Fisichella and BAR-Honda driver Takuma Sato both spun at the second corner and Button, Webber, Sato and Jordan pair Tiago Monteiro and Narain Karthikeyan all made mistakes at turn 14 during the session.
Raikkonen set the fastest time as McLaren took control in the opening session with the Finn's lap of 1:34.253 putting him 0.193 seconds ahead of teammate Montoya with the two Renaults in third and fourth.
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