Misano MotoGP: Marquez leads Pedrosa in first practice

The Spaniard hit the front early on and was never displaced as he improved several times to eventually end the session on a 1m34.476s.

Pedrosa fought back from early brake issues to jump the two works Yamahas and settle into second, just over two tenths down on his championship-leading team-mate.

Lorenzo, who ended Marquez's string of wins last time out at Silverstone, eventually claimed third ahead of team-mate Valentino Rossi, the pair trading blows several times during the session.

Both men were half a second off Marquez's time, in what was an encouraging first competitive run-out for Yamaha's new seamless gearbox.

Alvaro Bautista and Stefan Bradl made it four Hondas in the top six, while Nicky Hayden beat works Ducati stable-mate Andrea Dovizioso to seventh. The American was the last man to get within one second of Marquez.

Pramac's stand-in rider Michelle Pirro claimed ninth, with Aspar CRT man Aleix Espargaro rounding out the top 10.

It was a disappointing session for Yamaha's satellite Tech 3 squad.

On the back of a horrible home round, Cal Crutchlow struggled with rear balance and was only 11th fastest, two places ahead of team-mate Bradley Smith.

Pos Rider             Team                       Time              Laps
 1. Marc Marquez      Honda                      1m34.476s           21
 2. Dani Pedrosa      Honda                      1m34.698s  +0.222s  18
 3. Jorge Lorenzo     Yamaha                     1m34.902s  +0.426s  19
 4. Valentino Rossi   Yamaha                     1m34.978s  +0.502s  22
 5. Alvaro Bautista   Gresini Honda              1m35.269s  +0.793s  21
 6. Stefan Bradl      LCR Honda                  1m35.299s  +0.823s  22
 7. Nicky Hayden      Ducati                     1m35.392s  +0.916s  20
 8. Andrea Dovizioso  Ducati                     1m35.504s  +1.028s  17
 9. Michele Pirro     Pramac Ducati              1m35.725s  +1.249s  19
10. Aleix Espargaro   Aspar Aprilia              1m35.800s  +1.324s  17
11. Cal Crutchlow     Tech 3 Yamaha              1m35.913s  +1.437s  17
12. Hector Barbera    Avintia FTR-Kawasaki       1m36.198s  +1.722s  20
13. Bradley Smith     Tech 3 Yamaha              1m36.198s  +1.722s  20
14. Colin Edwards     Forward FTR-Kawasaki       1m36.652s  +2.176s  20
15. Hiroshi Aoyama    Avintia FTR-Kawasaki       1m36.661s  +2.185s  20
16. Randy de Puniet   Aspar Aprilia              1m36.764s  +2.288s  20
17. Andrea Iannone    Pramac Ducati              1m36.839s  +2.363s  20
18. Danilo Petrucci   Ioda-Suter-BMW             1m36.943s  +2.467s  23
19. Claudio Corti     Forward FTR-Kawasaki       1m37.252s  +2.776s  21
20. Yonny Hernandez   PBM Aprilia                1m37.329s  +2.853s  17
21. Karel Abraham     Cardion Ducati             1m37.688s  +3.212s  17
22. Michael Laverty   PBM-Aprilia                1m38.872s  +4.396s  18
23. Bryan Staring     Gresini FTR-Honda          1m39.024s  +4.548s  21
24. Lukas Pesek       Ioda-Suter-BMW             1m39.705s  +5.229s  17