Marc Marquez concedes that Mugello could be one of the most testing rounds of his debut MotoGP campaign.
Aside from retirements, the Italian track was the only venue at which Marquez failed to finish on the podium during his run to last year's Moto2 crown.
The Spaniard, who lost the championship lead to Dani Pedrosa following a wet Le Mans race, stressed the importance of hitting the ground running at the Italian venue.
"Mugello is perhaps one of the most difficult [circuits] in the world championship," Marquez said.
"It has many changes of direction so we must work hard from the beginning to find the right set up.
"These coming races will be very important as they are difficult circuits and we must remain focused.
"The other riders are so fast in Mugello so I'm sure it's going to be tough, but as always we will try our 100 per cent."
The 20-year-old did triumph at Mugello during his 2011 Moto2 campaign and also the previous year in 125cc, when he fought his way through from sixth on the grid.
His works Honda stablemate Dani Pedrosa, whose dominant win at Le Mans moved him into an six-point championship lead, added: "Mugello is a nice track and one that I really enjoy to ride.
"It's a fast track with long corners so it's important to have a good feeling with the bike.
"I've managed to relax this week and I feel good physically, so I hope we can arrive in Mugello, the bike works well there too and we can do a good race."