Brian Vickers will replace the injured Tony Stewart in the Stewart-Haas Chevrolet team for the 2016 NASCAR Sprint Cup opening Daytona 500.
Vickers suffers from blood clot issues and is unable to compete full-time.
He will be announced as Stewart's replacement on Friday at Daytona International Speedway provided NASCAR gives him medical clearance to race.
The 32-year-old three-time Cup race winner cannot compete when being treated for the clots because the blood thinners increase his risk of serious internal bleeding if he crashes.
Stewart suffered a burst fracture of the L1 vertebra when he was involved in an all-terrain vehicle crash on January 31 in California.
The team's plan is for Vickers to stand in at Daytona only while SHR looks for another driver for the rest of Stewart's absence.
Vickers has been sidelined four different times for health issues since 2010.
During a 25-race absence in 2010, he underwent a pair of procedures, one to close a hole in his heart and another to insert a stent into a vein in his left leg.
Vickers was hoping to compete last season, but surgery in December 2014 to repair a hole in his heart sidelined him for the first two races.
His body had been rejecting the artificial patch he received five years earlier.
He only managed two further races before blood clots returned, and the need for blood thinners sidelined him for the rest of the year.